Ethan Ostrom, a post-doctoral scholar in the Translational Bioenergetics Lab, was recently awarded a Young Investigator Award for presenting his work at the Society for Redox Biology and Medicine in Savannah, Georgia. Ethan has a longstanding interest in mitochondrial function and redox signaling. His work uses a new mouse model of mitochondrial oxidative stress that can be turned on and off by introducing a compound in the food or water of mice. This new model shows that inducing mitochondrial oxidative stress causes impaired metabolic function. This impairment is characteristic of the skeletal muscle metabolic impairments found in diabetes and insulin resistance. Reversing the mitochondrial oxidative stress in this model restores normal metabolic function. This work was published recently in Free Radical Biology & Medicine Journal and has implications for therapies targeting mitochondrial oxidative stress in metabolic diseases and aging skeletal muscle.

Article Link: doi.org/10.1016/j.freeradbiomed.2024.10.310