Marcinek Lab


July 10, 2020

New paper describes how targeting mitochondrial redox stress can reverse diastolic dysfunction in aged mice

A new paper in eLife by Ann Chiao from her work in the Rabinovitch Lab describes how reducing mitochondrial redox stress pharmacologically with elamipretide (SS-31) or genetically with mCAT can reverse age-related diastolic dysfunction. This work is noteworthy because it builds on previous work from the Marcinek and Rabinovitch Labs demonstrating that late life treatment…

June 29, 2020

David Marcinek Receives Distinguished Investigator Award

David Marcinek was named to the 2020 Council of Distinguished Investigators of the Academy for Radiology & Biomedical Imaging Research. This award acknowledges individuals for their achievements in the field of academic imaging research.

New insights into SS-31 (elamipretide) protein interactions

A collaboration between the Bruce and Marcinek labs using chemical cross-linking with mass spectroscopy (XL-MS) developed in the Bruce lab at the UW identified 12 mitochondria proteins that directly interact with the mitochondrial targeted peptide SS-31 (aka elamipretide, Bendavia). This study, published in PNAS and summarized on Newswise, suggests new targets to test the mechanisms underlying…

April 30, 2020

Liu et al. publication recognized as one of top downloaded papers

The 2018 Liu et al. paper, Building strength, endurance, and mobility using an astaxanthin formulation with functional training in elderly, has been recognized as one of the top 10% downloaded papers published in the Journal of Cachexia, Sarcopenia and Muscle between January 2018 and December 2019. This was the first and is still the only…

April 9, 2020

Olympic Dream on Hold for Researcher/Runner Sophia Liu

While working full time as a research scientist, Sophia Liu has been pursuing a highly-coveted spot for non-professionals on the Chinese Olympic Marathon Team. Last December she moved closer to reaching that goal with a top 5 finish in the 2019 Guangzhou Marathon, becoming the only Chinese non-professional athlete to qualify under the new Olympic…

April 7, 2020

Ana Valencia Awarded Position on Nutrition, Obesity, and Atherosclerosis Training Grant

Ana Valencia was awarded a position on the Nutrition, Obesity, and Atherosclerosis training grant (T32) through the Division of Metabolism, Endocrinology, and Nutrition. She will investigate the effects of sugar consumption on cardiovascular risk of the aging heart as a new direction from her current work studying the influence of high fat and high sugar…

January 28, 2020

Alicia Hendrix Presents at the Environmental Pathology and Toxicology Training Grant Retreat

December 19, 2019

Kevin Nguyen Named Mary Gates Research Scholar

Congratulations to Kevin Nguyen for being named a Mary Gates Research Scholar! Kevin is currently studying the effects of a mitochondrial targeted drug on muscle mass and function in an accelerated model of sarcopenia and will present his findings at the UW Undergraduate Research Symposium in May 2020.

October 17, 2019

Marcinek lab represented at NHLBI Mitochondrial Symposium

Dave Marcinek presented an invited lecture, “Mitochondrial Energetics of Aging Skeletal Muscle: from Organelle to In Vivo,“ at the 2019 NHLBI Mitochondrial Biology Symposium on Mitochondrial Networks and Engergetics. This symposium brought together experts in mitochondrial energy metabolism with those studying mitochondrial dynamics and membrane structure.

May 28, 2019

Kevin Nguyen presents at the UW Undergraduate Research Symposium

Kevin Nguyen presented his poster, “Effect of SS-31 on SOD1KO Model of Sarcopenia,” on May 17, 2019 at the UW Undergraduate Research Symposium. Kevin is studying whether early intervention with a mitochondrial targeted drug can preserve muscle mass and function in a genetic mouse model of accelerated sarcopenia. Congratulations to Kevin on the nice pilot…

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