Marcinek Lab


February 26, 2019

Rudy Stuppard recognized at the 2019 UW Distinguished Staff Nomination Ceremony

David Marcinek invited to present at the “Mitochondria in Age and Age-related Disease” Keystone Meeting in January 2019

Dave presented a talk titled “The Effects of Mitochondrial Redox Stress on Energetics and the Proteome in Aged Skeletal Muscle” in Keystone, CO. He summarized work from the Marcinek lab and collaborators examining how the interaction between mitochondrial dysfunction and changes in post-translational modifications with age affect energetics and muscle function. Some of this work…

Rudy Stuppard celebrates 30 years at the University of Washington

Rudy Stuppard was recognized for 30 years of service at the University of Washington. Rudy came to the University of Washington from Harvard with Dr. Martin Kushmerick. After working with Drs. Kushmerick and Conley for several years Rudy began working with the Marcinek lab in 2005. Since then he has been instrumental to the lab’s…

January 24, 2019

Aged muscle function and redox status improved by SS-31

Matt Campbell et al. have recently published in the journal of Free Radical Biology and Medicine a new study demonstrating improved redox status and function in aged skeletal muscle by 8 week treatment with SS-31. In this original research article the authors treated aged mice for 8 weeks with or without a mitochondrial targeted peptide….

April 24, 2018

Environmental toxicology study coauthored by postdoc Andrew Yeh receives press

A publication (Meador et al., 2018) coauthored by postdoc Andrew Yeh has been receiving press. The study is a continuation of Yeh’s doctoral research which investigated the effects of drugs in wastewater on Puget Sound Chinook salmon. Current wastewater treatment processes do not specifically target removal of pharmaceuticals and personal care products, and thus these…

December 4, 2017

Philip Kramer wins Young Investigator Award at the SFRBM annual Meeting

Philip Kramer recently received the Young Investigator Award at the Society for Redox Biology and Medicine’s annual meeting in Baltimore (2017) for his work “Fatiguing Contractions Induce Acute Redox Signaling in Mouse Muscle.” His work describes how the oxidants produced during exercise modify muscle proteins. These exciting results are part of a manuscript currently in…

September 11, 2017

Yeh et al. publish paper on “Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon”

The medicine, personal care products, and cleaning supplies that we use on a daily basis constitute a unique class of environmental pollutants termed “contaminants of emerging concern” (CECs). When excreted or washed away, these compounds enter wastewater treatment plants (WWTPs) but are not specifically targeted for removal. As a result, WWTP effluent introduces kg/day loads…

May 18, 2017

Lab member Dr. Philip A Kramer wins the Jim Baen Memorial Award for his SciFi short story “Feldspar”

Hosted by the National Space Society and Baen Books, the Jim Baen Memorial Short Story Award seeks SciFi stories set in the near future that positively portray human space exploration. Philip submitted “Feldspar,” a story about a Mars rover operator who finds himself in the unique and terrifying position to save the life of an…

March 30, 2017

New paper from Ferriss et al., describing higher than expected exposure to the seafood toxin domoic acid in the WA state coastal razor clam fishery

Ferriss et al. recently found that exposure to the naturally produced neurotoxin domoic acid (DA) through the recreational razor clam (Siliqua patula) fishery in Washington State may be larger than previously thought. DA is a neurotoxin naturally produced by phytoplankton and that accumulates in seafood during harmful algal blooms. As the prevalence of DA increases…

March 20, 2017

Schweppe et al. publish groundbreaking paper in PNAS describing protein interactions in the mitochondria

Mitochondria play a critical role in the pathology of chronic diseases and aging due to their status as the primary link between energy metabolism, oxidative stress and control of cell signaling. The complexes of the electron transport system are typically illustrated as a linear chain in the mitochondrial inner membrane (cristae). However, it is now…

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