The overriding theme of research in the TBL is the interaction between mitochondria and cell stress and its effect on the pathology of chronic disease and aging. Much of our work focuses on skeletal muscle and mobility in aging, but given the broad impact of mitochondria our interests span multiple systems and diseases. Our work focuses on: 

• MRS to measure in vivo mitochondrial function of skeletal muscle in humans and heart in rodents. 
• Using high-sensitivity imaging measurements in vivo o identify factors that underlie aging and disease in humans and animals . 
• Testing novel approaches that reverse mitochondrial, muscle and vascular dysfunction with age and disease.
• Understanding the molecular changes in the mitochondria that lead to changes to in vivo metabolism and contribute to disease.
• Developing a pre-clinical to clinical pipeline to test new mitochondrial targeted interventions to improve health span.
• Combining systems analyses of in vivo energetics and gene expression data to study regulation of mitochondrial function.