- Congratulations to Ethan Ostrom, Postdoctoral Scholar in the Translational Bioenergetics Lab, on Receiving a Young Investigator Award!Ethan Ostrom, a post-doctoral scholar in the Translational Bioenergetics Lab, was recently awarded a Young Investigator Award for presenting his work at the Society for Redox Biology and Medicine in Savannah, Georgia. Ethan has a longstanding interest in mitochondrial function and redox signaling. His work …
- New Marcinek/Regnier grant to study targeting the mitochondria in the aging heartThe Marcinek and Regnier lab just received a new R01 from the NIA to study the mechanisms by which treatment with urolithin A, a mitochondrial targeted intervention improves energetics and contractile function in the aging heart.
- 2024 NIA Summer Training Course is open for applicationsThe 31st Annual Summer Training Course provides intense exposure to current concepts in experimental aging research to approximately 20 research scientists to facilitate development of independent research programs in the basic biology of aging. It is primarily designed for junior faculty and advanced fellows with …
- David Marcinek gives Lab Medicine and Pathology Research and Discovery Seminar
David Marcinek delivered the presentation, “Mitochondria in Aging: Bench to Bedside and Back Again”, in the monthly DLMP seminar series on January 23, 2024. This presentation covered some of the work in the Marcinek lab over the last decade moving between basic mechanisms and clinical … - David Marcinek and Jessica Young named co-directors of the UW Nathan Shock Center of Excellence in the Basic Biology of AgingThe UW Nathan Shock Center (NSC) is one of 8 NIA funded P30 centers whose mission is to provide leadership and resources to advance research into the basic mechanisms driving aging. Aging is the single greatest risk factor for nearly all chronic diseases so a …
- Bakhtina and Pharaoh et al. paper on “Skeletal muscle mitochondrial interactome remodeling is linked to functional decline in aged female mice.”
Anna Bakhtina and Gavin Pharaoh et al. recently published a new study in the high impact journal Nature Aging identifying that “Skeletal muscle mitochondrial interactome remodeling is linked to functional decline in aged female mice.” Aging is a complex process involving many biological changes leading … - Campbell et al. paper on “Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice”.
Matthew Campbell et al. have recently published a new study in the journal of Geroscience demonstrating, “Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice.” Elamipretide (ELAM) is a short tetrapeptide that interacts with cardiolipin and cardiolipin-interacting proteins on the inner mitochondrial membrane. … - Mischley et al. paper on “ATP and NAD+ Deficiency in Parkinson’s Disease”, published in Nutrients 2023.
Mischley et al. has published a new paper with a goal to identify a signature of bioenergetic and functional markers in the muscles of individuals with Parkinson’s disease (PD). The study shows that the mitochondrial dysfunction (low NAD+ and ATP) is associated with worse PD … - Alicia Hendrix has been awarded a Christine Mirzayan Science and Technology Policy Graduate Fellowship.
Alicia Hendrix has been awarded a Christine Mirzayan Science and Technology Policy Graduate Fellowship with the National Academies of Sciences, Engineering, and Medicine (NASEM). Alicia will work jointly with the Gulf Research Program’s Gulf Health and Resilience Board (GHRB) and their Gulf Environmental Protection and Stewardship Board … - Berry et al. article on mitochondrial control over the aging process in nematode worms.
Berry et al. have recently published an article on Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan demonstrating mitochondrial control over the aging process in the nematode worm model. Their findings show that optogenetically increasing mitochondrial membrane potential during adulthood using a light-activated … - Valencia et al. paper on “Aging increases susceptibility to develop cardiac hypertrophy following high sugar consumption”.
Valencia et al. paper describing “How aging increases susceptibility to develop cardiac hypertrophy following high sugar consumption”, published in Nutrients December 2022. Aging and poor nutrition are risk factors for heart disease, and pathological cardiac hypertrophy can lead to heart failure. High sugar consumption is … - Campbell et al. article ( “Elamipretide effects…”) published in the journal of Geroscience.Matthew Campbell et al. have recently published a new study in the journal of Geroscience demonstrating Elamipretide effects on the skeletal muscle phosphoproteome in aged female mice. Elamipretide (ELAM) is a short tetrapeptide that interacts with cardiolipin and cardiolipin-interacting proteins on the inner mitochondrial membrane. …
- Brandon’s webinar: MITOtalks online series.Brandon Berry will talk about “Preserving Mitochondrial Energetics with Age using Optogenetics” in a webinar, organized by Twitter based group @MitOtalks. To register, please send email with subject line “Join MITOtalks” to MITOtalks@gmail.com To follow their twitter page, please go to https://twitter.com/MitOtalks. Date: October 20th, …
- Gavin’s talk: UW CTMR Annual Symposium.
Gavin Pharaoh will be presenting his work on “ADP Insensitivity in Muscle Aging” at the 2022 UW CTMR Annual Symposium – UW Center for Translational Muscle Research. To register for the talk, please use the following link: https://ctmr.washington.edu/2022-uw-ctmr-annual-symposium/ - Matthew D. Campbell speaks at The Diabetes and Metabolism Seminar Series.The Diabetes and Metabolism Seminar Series and NW-MRC Center Presents: Nutrition, Metabolism and Metabolomics: New Frontiers and Intersections — where Matthew D. Campbell presents his work on “Muscle contraction induced changes to mitochondrial substrate use”. To register for the talk, please use the following link: …
- Ana receives the SLU Trainee of the Year AwardAna Valencia was selected as the recipient of this year’s SLU Trainee of the Year Award by UWMDI (UW Medicine Diabetes Institute). She also gave a talk at the Diabetes Day event on Wednesday May 25th, together with the VA Trainee of the Year Award recipient, Haiming Liu-Kerr. For more details, please check – …
- David Marcinek interviewed by “Live Long and Master Aging” podcast for a study.
Lab Director, Prof. David Marcinek was interviewed by Live Long and Master Aging podcast about a recent study – Testing a mitochondrial targeted intervention to improve aging muscle health. The study was designed to test the hypothesis that long-term supplementation with Mitopure, a highly pure, … - Alicia presents her work at the Society for Marine Mammalogy.
Alicia Hendrix talks about “Ice seals as sentinels for algal toxin presence in Alaska”. The algal-produced neurotoxins domoic acid and saxitoxin permeate food webs in the Alaskan Arctic and subarctic, potentially threatening the health of high-level consumers. As water temperatures continue to rise in the … - New TBL paper demonstrates that a single treatment with elamipretide reverses the decline in ATP production in skeletal muscle of older adultsThe paper by Roshanravan et al. “In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial”, appeared in the journal PLoS one in July 2021. Older subjects were selected for low in vivo …
- Ana Valencia presents at the NORC/CORA Annual Symposium (12/09/2021)Ana Valencia will be presenting her work on “Impact of Nutrition Stress on Mitochondria in the Context of Obesity and Aging“, at the NORC/CORA Annual Symposium: From Cells to Society: Fostering Communities Involved in Obesity and Nutrition Research, on December 9th 2021 (9:15 am-1:00 pm …
- Ana Valencia speaks at the Future of Aging Seminar (11/17/2021)Ana Valencia, Ph.D. will be discussing recent work on high fat and high sugar diets in the context of aging this November 17th at the Future of Aging seminar organized by the University of Washington Retirement Association in partnership with the University of Washington Alumni Association. The …
- Liu et al. paper on “Astaxanthin supplementation enhances metabolic adaptation with aerobic training in the elderly”Liu et al. have published a new study in the journal of Physiological Reports demonstrating how Astaxanthin supplementation enhances metabolic adaptation with aerobic training in the elderly. Endurance training (ET) improves metabolic health and aerobic capacity. However, ET-induced adaptations may be suboptimal due to oxidative …
- Valencia et al. paper on “Are fat and sugar just as detrimental in old age?”Valencia et al. have recently published a review in the journal of Geroscience addressing the question “Are fat and sugar just as detrimental in old age?” They argue that that obesogenic, high-fat diets can exacerbate age-related disease and hallmarks of aging in young animals, but …
- Ostrom et al. paper on “High intensity muscle stimulation activates a systemic Nrf2-mediated redox stress response”
Ethan Ostrom et al. have recently published in the journal of Free Radical Biology and Medicine a new study demonstrating the muscular redox stress response to high intensity muscle stimulation vs low intensity muscle stimulation. The authors found that there were no differences in redox stress … - Ana Valencia speaks at the UW Nathan Shock Center Geroscience Symposium.
Dr. Ana Valencia presented her work on the effects of nutritional stress in aging mice at the Annual Geroscience Symposium hosted by the UW Nathan Shock Center and HALO Research Institute. She discussed her unexpected findings on the predisposition of the aging heart to sugar consumption, …