• Researcher, Mitochondria and Metabolism Center

• Associate Professor, Anesthesiology and Pain Medicine

• Adjunct Associate Professor of Pathology

Research Interests

• Cardiovascular bioenergetics and mitochondrial function regulation
• Metabolic pathways and therapeutic targets in heart failure
• Mitochondrial dysfunction in neurodegenerative disease
• Confocal imaging and in vivo evaluation of mitochondrial function

Awards

• National Institutes of Health, Fellow Award for Research Excellence (2003 & 2004)
• International Society for Heart Research (ISHR), Richard J. Bing Award for Young Investigators (2007)
• The Academy of Cardiovascular Research Excellence (ACRE) Young Investigator Award (2011)
• American Diabetes Association (ADA) Gail Patrick Innovation Award (2015)
• American Heart Association (AHA) Established Investigator Award (2018)

 Current Memberships

• American Heart Association
• American Physiological Society
• American Society for Biochemistry and Molecular Biology

 Current Funding

• National Institutes of Health (R01): Dynamin-Related Protein Drp1 Regulates Cardiac Excitation-Contraction-Bioenergetics Coupling.
• American Heart Association (EIA): Mitochondrial fission protein DRP1 in metabolic heart disease.

Recent Publications

• Wang Wang, Celia Fernandez-Sanz. Shey-Shing Sheu. Regulation of mitochodrial bioenergetics by the non-canonical roles of mitochondrial dynamics proteins in the heart. Biochim Biophys Acta. 1864, 1991-2001, 2018.
• Huiliang Zhang, Pei Wang, Sara Bisetto, Yisang Yoon, Quan Chen, Shey-Shing Sheu, Wang Wang. Novel role of DRP1 in cardiac mitochondrial respiration. Cardiovasc Res. 113, 160-170, 2017.
• Shangcheng Xu, Pei Wang, Huiliang Zhang, Guohua Gong, Nicolas Gutierrez Cortes, Weizhong Zhu, Yisang Yoon, Rong Tian, Wang Wang. CaMKII induces transient permeability transition through Drp1 phosphorylation during chronic b-AR stimulation. Nat Commun. 7, 13189, 2016.
• Wang Wang, Guohua Gong, Xianhua Wang, Lan Wei-LaPierre, Heping Cheng, Robert Dirksen, Shey-Shing Sheu. Mitochondrial Flash: Integrative ROS and pH Signals in Cell and Organelle Biology. Antioxid. Redox Signal. 25, 534-549, 2016.
• Wang Wang, Georgios Karamanlidis, Rong Tian. Novel targets for mitochondrial medicine. Sci Transl Med. 8, 326-333, 2016.
• Guohua Gong, Xiaoyun Liu, Huiliang Zhang, Shey-Shing Sheu, Wang Wang. Mitochondrial flash as a novel biomarker of mitochondrial respiration in the heart. Am J Physiol Heart Circ Physiol. 309, H1166-1177, 2015.
• Guohua Gong, Xiaoyun Liu, Wang Wang. Regulation of metabolism in individual mitochondria during excitation-contraction coupling. J Mol Cell Cardiol. 76, 235, 2014.
• Jin O-Uchi, Bong Sook Jhun, Shangcheng Xu, Stephen Hurst, Anna Raffaello, Xiaoyun Liu, Bing Yi, HuIliang Zhang, Polina Gross, Jyotsna Mishra, Alina Ainbinder, Sarah Kettlewell, Godfrey L. Smith, Robert T. Dirksen, Wang Wang, Rosario Rizzuto, Shey-Shing Sheu. Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxid. Redox Signal. Antioxid Redox Signal. 21, 863, 2014.

Laboratory:  Wang Lab