Julia Ritterhoff, PhD

Research Interests

• Metabolic remodeling and therapeutic targets in heart failure
• Rewiring of substrate metabolism in cardiac diseases
• Metabolomics and metabolic flux analysis

Honors and Awards

2020 ITHS Early Investigator Catalyst Award
2019 Finalist, UW Postdoc Mentoring Award
2019 Cambridge Isotope Laboratories, Inc. Research Award
2018 New Investigator Travel Award, American Heart Association (AHA)
2016 Postdoctoral Research Fellowship, German Research Foundation (DFG)

List of Published Work in MyBibliography https://www.ncbi.nlm.nih.gov/myncbi/1N5NA_7avj8Ak/bibliography/public/

Selected Publications

1. Ritterhoff J, Young S, Villet O, Shao D, Carnevale Neto F, Bettcher LF, Hsu YW, Kolwicz S Jr, Raftery D, Tian R. Metabolic remodeling promotes cardiac hypertrophy by directing glucose to aspartate biosynthesis. Circ Res. 2020 Jan 17;126(2):182-196
2. Yang X, Rodriguez M, Leonard A, Sun L, Fischer KA, Ritterhoff J, Zhao L, Kolwicz Jr S, Pabon L, Reinecke H, Sniadecki NJ, Tian R, Ruohola-Baker H, Xu H, Murry CE. Fatty Acids Affect the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells. Stem Cell Reports. 2019 Oct 8;13(4):657-668
3. Shao D, Villet O, Zhang Z, Choi SW, Yan J, Ritterhoff J, Gu H, Djukovic D, Christodoulou D, Kolwicz Jr S, Raftery D, Tian R. Glucose Promotes Cell Growth by Suppressing Branched-chain Amino Acid Degradation. Nat Commun. 2018 Jul 26;9(1):2935
4. Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J. A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway. Nat Med. 2018 Jan;24(1):62-72.
5. Ritterhoff J and Tian R (review). Metabolism in cardiomyopathy – every substrate matters. Cardiovasc Res. 2017 Mar 15;113(4):411-421
6. Li T, Zhang Z, Kolwicz SC Jr, Abell L, Roe ND, Kim M, Zhou B, Cao Y, Ritterhoff J, Gu H, Raftery D, Sun H, Tian R. Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury. Cell Metab. 2017 Feb 7;25(2):374-385.
7. Ritterhoff J*, Völkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RH, Koch WJ, Katus HA, Most P*. S100A1 DNA-based inotropic therapy protects against proarrhythmogenic ryanodine receptor 2 dysfunction. Mol Ther. 2015 Aug;23(8):1320-30.
   *Co-corresponding author

8. Ritterhoff J, Most P (review). Targeting S100A1 in heart failure. Gene Ther. 2012 Jun;19(6):613-21.