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Haiwei Gu, PhD

 Haiwei Gu

Research Interests

My research interests focus on NMR- and MS-based metabolomics and its applications in early disease diagnosis, drug metabolism, and biological sciences. Currently, I am working closely with a number of clinical researchers and practitioners in various studies for identifying metabolic markers useful to detect cancer recurrence, investigating cancer metabolism using cell/mitochondria models, and examining the metabolic remodeling during pressure-overload hypertrophy, as well as comprehensively profiling age-dependent changes of cardiac metabolites.

 

Honors and Awards

2007                       ENC Student Stipend Award
2008                       ASMS Student Assistantship
2013                       ITHS Award, Institute of Translational Health Sciences
2015                       Rising Stars, Institute of Translational Health Sciences
2015                       Agilent Young Investigator Award

 

Current Memberships

2006-2007               Member, Experimental Nuclear Magnetic Resonance Conference

2007-                      Member, American Chemical Society

2007-                      Member, American Society for Mass Spectrometry

2008-                      Member, Metabolomics Society

2010                       Member, Minnesota Chromatography Forum

 

SelectedPublications (out of 41 Peer-reviewed Publications, 12/16/15)

 

  1. H. Gu+*, P. Zhang+, J. Zhu, D. Raftery, “Globally Optimized Targeted Mass Spectrometry: Reliable Metabolomics Analysis with Broad Coverage”, Anal. Chem., 87, 12355-12362, 2015. PMCID:   26579731
  2. H. Gu*, J. Du, F. Carnevale Neto, P. Carroll, S. Turner, G. Chiorean, R. Eisenman, D. Raftery, “Metabolomics Method to Comprehensively Analyze Amino Acids in Different Domains”, Analyst, 140, 2726-2734, 2015. PMCID: PMC4380628
  3. P. Carroll, D. Diolaiti, L. McFerrin, H. Gu, D. Djukovic, J. Du, P. Cheng, S. Anderson, M. Ulrich, J. Hurley, D. Raftery, D. Ayer, R. Eisenman*, “Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis”, Cancer Cell, 27, 271-285, 2015. PMCID: PMC4326605
  4. N. Reyes, G. Banks, M. Tsang, D. Margineantu, H. Gu, D. Djukovic, J. Chan, M. Torres, H. Liggitt, D. Hirenallur-S, D. Hockenbery, D. Raftery, B. Iritani*, “Fnip1 Regulates Skeletal Muscle Fiber Type Specification, Fatigue Resistance, and Susceptibility to Muscular Dystrophy”, PNAS, 112, 424-429, 2015. PMCID: PMC4299192
  5. S. Pan, Y. Tian, M. Li, J. Zhao, L. Zhu, W. Zhang, H. Gu*, H. Wang, J. Shi, X. Fang, P. Li, H. Chen, “Quantitative Detection of Nitric Oxide in Exhaled Human Breath by Extractive Electrospray Ionization Mass Spectrometry”, Sci. Reports, 5, 8725, 2015. PMCID: PMC4348632
  6. W. Yao, H. Gu, J. Zhu, G. Barding, H. Cheng, B. Bao, L. Zhang*, A. Ding*, W. Li, “Integrated Plasma and Urine Metabolomics Coupled with HPLC/QTOF-MS and Chemometric Analysis on Potential Biomarkers in Liver Injury and Hepatoprotective Effects of Er-Zhi-Wan”, Anal. Bioanal. Chem., 406, 7367-7378, 2014. PMID: 25245419
  7. J. Zhu, D. Djukovic, L. Deng, H. Gu, F. Himmati, E. Chiorean, D. Raftery*, “Colorectal Cancer Detection Using Targeted Serum Metabolic Profiling”, J. Proteome Res., 13, 4120-4130, 2014. PMID: 25126899
  8. H. Gu, A. N. Gowda, F. Carnevale Neto, M. Opp, D. Raftery*, “RAMSY: Ratio Analysis of Mass Spectrometry to Improve Compound Identification”, Anal. Chem., 85, 10771-10779, 2013. PMCID: PMC3867450
  9. F. Tayyari, A. N. Gowda, H. Gu, D. Raftery*, “15N-Cholamine-A Smart Isotope Tag for Combining NMR- and MS-Based Metabolite Profiling”, Anal. Chem., 85, 8715-8721, 2013. PMCID: PMC3803152
  10. H. Gu, A. N. Gowda, D. Raftery*, “Metabolic Profiling: Are We en route to Better Diagnostic Tests for Cancer?”, Future Oncol., 8, 1207-1210, 2012. PMID: 23130920
  11. H. Gu, Y. Huang, M. Filgueira, P. W. Carr*, “Effect of First Dimension Phase Selectivity in Online Comprehensive Two Dimensional Liquid Chromatography (LCxLC)”, J. Chrom. A., 1218, 6675-6687, 2011. PMCID: PMC3256932
  12. H. Gu, Z. Pan, B. Xi, V. Asiago, B. Musselman, D. Raftery*, “Principal Component Directed Partial Least Squares Analysis for Combining NMR and MS Data in Metabolomics: Application to the Detection of Breast Cancer”, Anal. Chim. Acta, 686, 57-63, 2011. PMCID: PMC3040422
  13. A. N. Gowda, S. Zhang, H. Gu, V. Asiago, N. Shanaiah, D. Raftery*, “Metabolomics-Based Methods for Early Disease Diagnostics: A Review”, Expert Rev. Mol. Diagnos., 8, 617-33, 2008. PMCID: PMC3890417
  14. H. Gu, H. Chen, Z. Pan, A. U. Jackson, N. Talaty, B. Xi, C. Kissinger, C. Duda, D. Mann, D. Raftery*, R. G. Cooks*, “Monitoring Diet Effects from Biofluids and Their Implications for Metabolomics Studies”, Anal. Chem., 79, 89-97, 2007. PMID: 17194125
  15. H. Chen, Y. Sun, A. Wortmann, H. Gu, R. Zenobi*, “Differentiation of Maturity and Quality of Fruit Using Noninvasive Extractive Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry”, Anal. Chem., 79, 1447-1455, 2007. PMID: 17297943

 

Contact Information

Mitochondria and Metabolism Center
850 Republican St, Room N121
Seattle, WA  98109-8057
Phone: 206-685-4753
Fax: 206-616-4819

Email:haiwei@uw.edu